Chromatin target of PRMT1 is a protein that in humans is encoded by the CHTOP gene .
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Function This gene encodes a small nuclear protein that is characterized by a arginine and glycine rich region. The encoded protein may be involved in cell cycle progression. This protein interacts with protein arginine methyltransferases and plays a role in the activation of estradiol-dependent transcription. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].
References Further reading
Zullo, A. J.; Michaud, M; Zhang, W; Grusby, M. J. (2009). "Identification of the small protein rich in arginine and glycine (SRAG): A newly identified nucleolar protein that can regulate cell proliferation" . Journal of Biological Chemistry . 284 (18): 12504–11. doi :10.1074/jbc.M809436200 . PMC 2673316 PMID 19254951 . Chang, C. T.; Hautbergue, G. M.; Walsh, M. J.; Viphakone, N; Van Dijk, T. B.; Philipsen, S; Wilson, S. A. (2013). "Chtop is a component of the dynamic TREX mRNA export complex" . The EMBO Journal . 32 (3): 473–86. doi :10.1038/emboj.2012.342 . PMC 3567497 PMID 23299939 . Teng, I. F.; Wilson, S. A. (2013). "Mapping interactions between mRNA export factors in living cells" . PLoS ONE . 8 (6): e67676. doi :10.1371/journal.pone.0067676 . PMC 3691119 PMID 23826332 . Van Dijk, T. B.; Gillemans, N; Stein, C; Fanis, P; Demmers, J; Van De Corput, M; Essers, J; Grosveld, F; Bauer, U. M.; Philipsen, S (2010). "Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases" . Molecular and Cellular Biology . 30 (1): 260–72. doi :10.1128/MCB.00645-09 . PMC 2798285 PMID 19858291 . Van Dijk, T. B.; Gillemans, N; Pourfarzad, F; Van Lom, K; von Lindern, M; Grosveld, F; Philipsen, S (2010). "Fetal globin expression is regulated by Friend of Prmt1" . Blood . 116 (20): 4349–52. doi :10.1182/blood-2010-03-274399 . PMC 2993632 PMID 20688955 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
