Folate deficiency screening

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Screening

Screening for folate deficiency is not routinely recommended. However, early detection can lead to folic acid supplementation, which is a simple treatment of the underlying cause. can reduce the risk of anemia certain conditions such as fetal neural tube defects in newborns.

High risk populations

• Older people (Age >65)
• Alcohol abusers
• Pregnant or lactating women
• Preterm infants
• Lower socioeconomic groups
• Patients with intestinal malabsorption
• Patients with conditions with increased cell turnover states
• Patients on special diets, and infants given goats' milk
• Chronic dialysis patients.

Screening tests

CBC may show increased MCV i.e. MCV > 100fL with or without low hemoglobin.Further testing includes serum folate level (Adults: 2-20 ng/mL). High risk populations are tested for folate deficiency if their CBC is abnormal.