Endometrial cancer differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]Roukoz A. Karam, M.D.[3]
Overview
In early stages endometrial cancer must be differentiated from diseases that cause abnormal uterine bleeding and endometrial thickening on ultrasound, such as endometrial hyperplasia, endometrial polyp and submucosal uterine leiomyoma. In advanced stages endometrial cancer must be differentiated from uterine sarcoma and uterine lymphoma.
Differentiating Endometrial Cancer From Other Diseases
- In early disease, uterine cancer must be differentiated from other diseases causing endometrial thickening:[1]
- Benign endometrial proliferation
- Endometrial hyperplasia
- Endometrial polyp
- Submucosal uterine leiomyoma
- In advanced disease, uterine cancer must be differentiated from other diseases:[1]
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- Endometrial stromal sarcoma (ESS)
- Leiomyosarcoma of the uterus
- Malignant mixed Mullerian tumour (MMMT) of the uterus
- Uterine lymphoma: rare
- Primary uterine lymphoma
- Secondary uterine involvement with lymphoma
- Cervical cancer with uterine invasion
- Metastasis to the uterus from a non gynaecologcial malignancy: rare
| Diseases | Clinical manifestations | Para-clinical findings | Gold standard | Additional findings | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symptoms | Physical examination | |||||||||||||||
| Lab Findings | Imaging | Histopathology | ||||||||||||||
| Vaginal Bleeding | Pelvic Pain | Pelvic Pressure | Abdominal Distention | Pelvic Mass | Abdominaldistension | Physical exam 3 | Hb | CEA-19 | Pelvic
examination |
Pelvicultrasound | MRI | |||||
| Uterine cancer | ||||||||||||||||
| Uterine | ||||||||||||||||
| Uterine | ||||||||||||||||
| Uterine leiomyoma | ||||||||||||||||
| Malignant mixedMullerian
tumour (MMMT) of the uterus |
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| Cervical cancerwith
uterine invasion |
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| Metastasis to the uterusfrom a non gynaecologcial
malignancy |
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| Endometrial | ||||||||||||||||
| Endometrial | ||||||||||||||||
| Fetus | ||||||||||||||||
| Uterine | ||||||||||||||||
| Hematometra | ||||||||||||||||
References
- ↑ 1.0 1.1 Hippisley-Cox J, Coupland C (2011). "Identifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm". BMJ. 344: d8009. doi:10.1136/bmj.d8009. PMC 3251328. PMID 22217630.