Glioblastoma multiforme classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Marjan Khan M.B.B.S.[2]

Overview

Glioblastoma multiforme may be classified into several subtypes based on the origin (primary and secondary) and molecular alterations (classic, proneural, mesenchymal, and neural).^[1]^[2]

Classification

Based on the origin

Glioblastoma multiforme may be classified according to the origin into two subtypes: Primary and secondary.^[1]


Subtype of Glioblastoma multiforme	Characteristic features

Primary glioblastoma multiforme	De novo origin More aggressive Occurs in older patients
Secondary glioblastoma multiforme	Arises from pre-existing lower grade gliomas Less aggressive Occurs in younger patients

Based on the molecular alterations

Glioblastoma multiforme may be classified according to the molecular alterations into four subtypes:^[2]

Classic
Proneural
Mesenchymal
Neural

References

↑ ^1.0 ^1.1 Classification of Glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/Glioblastoma
↑ ^2.0 ^2.1 Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD; et al. (2010). "Integrated genomic analysis identifies clinically relevant subtypes of Glioblastoma multiforme characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1". Cancer Cell. 17 (1): 98–110. doi:10.1016/j.ccr.2009.12.020. PMC 2818769. PMID 20129251.

Template:WikiDoc Sources

[ddd-1] 1.0 ^1.1 Classification of Glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/Glioblastoma

[pmid20129251-2] 2.0 ^2.1 Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD; et al. (2010). "Integrated genomic analysis identifies clinically relevant subtypes of Glioblastoma multiforme characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1". Cancer Cell. 17 (1): 98–110. doi:10.1016/j.ccr.2009.12.020. PMC 2818769. PMID 20129251.

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