Leiomyosarcoma epidemiology and demographics
Overview:
Leiomyosarcoma is one the most common types of soft tissue sarcoma. Sarcomas of the uterine cervix constitute less than 1% of all cervical malignancies. Although leiomyosarcoma is one of the most common non-epithelial malignant neoplasms arising in soft tissue and somatic organs, while arising from the uterine cervix is extremely rare.
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Epidemiology and demographics
Leiomyosarcoma is a rare tumor subtype, accounts for 1% of all uterine malignancies, but contributes to a significant proportion of uterine cancer deaths. The incidence of uterine LMS is 0.36 per 100,000 woman-years; most occur in women over 40 years of age, with incidence increasing rapidly after age 50 [9]. Black women have a 2-fold higher incidence than white women. LMS may be associated with obesity and diabetes [6]. Tamoxifen use for N5 years may also increase LMS risk to 17 per 100,000 woman-years [7]. Additionally, studies in soft tissue sarcoma have attributed an increased risk of LMS with p53 gene mutations, radiation treatment for childhood cancers, and germ line mutations in fumarate hydratase (hereditary leiomyomatosis with renal cell carcinoma) [4]. Most uterine LMS is unassociated with preexisting leiomyomas and no biologic evidence exists to link LMS with their benign, smooth muscle uterine tumors. [1] Sarcomas of the uterine cervix constitute less than 1% of all cervical malignancies.[2] Although leiomyosarcoma is one of the most common non-epithelial malignant neoplasms arising in soft tissue and somatic organs, while arising from the uterine cervix is extremely rare.
Uterine sarcoma are extremely rare, with the incidence of 0.36 patients per 100,000 woman-years.[1] Black women have a 2-fold higher incidence of development of the uterine Leiomyosarcoma as compared to the white women.
References
- ↑ 1.0 1.1 Toro, Jorge R.; Travis, Lois B.; Wu, Hongyu Julian; Zhu, Kangmin; Fletcher, Christopher D.M.; Devesa, Susan S. (2006). "Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results program, 1978–2001: An analysis of 26,758 cases". International Journal of Cancer. 119 (12): 2922–2930. doi:10.1002/ijc.22239. ISSN 0020-7136.
- ↑ Dhull, A. K.; C, A.; Kaushal, V.; Marwah, N. (2013). "The uncovered story of leiomyosarcoma of the cervix: a rare case report and review of literature". Case Reports. 2013 (mar20 1): bcr2013008616–bcr2013008616. doi:10.1136/bcr-2013-008616. ISSN 1757-790X.