Paget's disease of the breast causes

Paget's disease of the breast Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Overview

The cause of Paget's disease of the breast has not been identified. There are two widely excepted hypothesis:

• The most widely accepted theory is that the disease results from an underlying intra-ductal breast carcinoma. The cancer cells are hypothesized to travel through lactiferous ducts to the nipple and its surrounding skin.
• Another theory is that the disease can develop independently in the nipple as an in-situ carcinoma.

Causes

The cause of Paget's disease of the breast has not been identified.