Paget's disease of the breast overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Paget's disease is an eczematous skin change of the nipple that is usually associated with an underlying breast malignancy. Paget's disease of the breast was first discovered by James Paget, a British surgeon and physiologist, in 1874. Paget's disease of the breast occurs in 1 – 4% of all female breast carcinoma cases. Mammary Paget's disease is almost always associated with an underlying breast cancer in 92–100% of cases. Approximately 50% of this patients present with an associated palpable mass in the breast. On microscopic histopathological analysis, epidermal Paget cells which are malignant glandular epithelial cells organized in groups with nest-like patterns or gland-like structures and are preferably located in the epidermal basal layer are characteristic findings of Paget's disease of the breast. Common risk factors in the development of Paget's disease of the breast are age, personal history of breast cancer, family history of breast cancer, irradiation, and genetic mutations. Symptoms of Paget's disease of the breast include itching, redness, thickened skin, and ulceration of the nipple. Common physical examination findings of Paget's disease of the breast include eczematous appearance of the nipple associated with yellowish or bloody discharge. Paget's disease of the breast must be differentiated from atopic dermatitis, eczema, psoriasis, malignant melanoma, Bowen's disease, basal cell carcinoma, and pagetoid dyskeratosis.[1][2] Biopsy may be helpful in the diagnosis of Paget's disease of the breast. Mammogram may be performed to detect the breast cancer associated with Paget's disease of the breast. Mastectomy is the mainstay of treatment for Paget's disease of the breast. Adjunctive radiation may be required.
Historical Perspective
Paget's disease of the breast was first discovered by James Paget, a British surgeon and physiologist, in 1874.The characteristic erythema and eczematous changes of the nipple seen with Paget’s disease of the breast were first described by Velpeau in 1856. The correlation between intraductal cancer and Paget’s disease of the breast was by Jacobeus in 1904.The background for the epidermotropic theory, that ducts containing carcinoma cells were apparently connected to overlying nipples containing Paget’s cells, was demonstrated by Muir and Inglis in 1939 and 1946 respectively. The first case of Paget's disease in a male was described by Elbogen in 1908.
Classification
There is no classification system established for Paget's disease of the breast.
Pathophysiology
On gross pathology, eczematoid, erythematous, moist or crusted lesion, with or without fine scaling, infiltration of the nipple, and inversion of the nipple are characteristic findings of Paget's disease of the breast. Eczema changes of the nipple-areolar complex are said to occur due to invasion of the overlying epidermis by malignant (Paget) cells.The commonly accepted hypothesis is that most cases of Paget's disease of the breast originate from in situ or invasive ductal carcinoma of the underlying breast tissue. On microscopic histopathological analysis, epidermal Paget cells which are malignant glandular epithelial cells organized in groups with nest-like patterns or gland-like structures and are preferably located in the epidermal basal layer characteristic of Paget's disease of the breast.On gross pathology nipple and areola show eczematoid, erythematous, moist or crusted lesions, with or without fine scaling, infiltration of the nipple, and inversion of the nipple are characteristic findings of Paget's disease of the breast.Immunohistochemistry is very useful in Paget's disease of the breast for differential diagnoses and histogenesis. The overexpression of the low molecular weight cytokeratins, notably CK7, and lack of expression of high molecular weight cytokeratins, such as CK10, CK14 and CK20 are observed in 98-100% of Paget's disease of the Breast.
Causes
Mutations predisposing patients to Paget's disease of the breast have not yet been described in the literature.It is currently hypothesized that intraepidermal cells of Paget's disease may be intrinsically genetically different than those of the underlying breast carcinoma.This has been seen by specific chromosomal alterations identified by loss of heterozygosity and mitochondrial DNA displacement loop sequence analysis.The most widely accepted theory is that the disease results from an underlying intra-ductal breast carcinoma. The cancer cells are hypothesized to travel through lactiferous ducts to the nipple and its surrounding skin. Another theory is that the disease can develop independently in the nipple as an in-situ carcinoma.
Differential Diagnosis
Paget's disease of the breast must be differentiated from atopic dermatitis, eczema, psoriasis, malignant melanoma, Bowen's disease, basal cell carcinoma, and pagetoid dyskeratosis.[1][2]
Epidemiology and Demographics
Risk Factors
Common risk factors in the development of Paget's disease of the breast are age, personal history of breast cancer, family history of breast cancer, irradiation, and genetic mutations.
Screening
According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for Paget's disease of the breast.[3]
Natural History, Complications and Prognosis
Diagnosis
Staging
There is no established system for the staging of Paget's disease of the breast.
History and Symptoms
Symptoms of Paget's disease of the breast include itching, redness, thickened skin, and ulceration of the nipple.
Physical Examination
Common physical examination findings of Paget's disease of the breast include eczematous appearance of the nipple associated with yellowish or bloody discharge.
Biopsy
Biopsy may be helpful in the diagnosis of Paget's disease of the breast. Findings on biopsy diagnostic of Paget's disease of the breast include presence of Paget cells, which are arranged in solid groups.[1]
Ultrasonography
Ultrasonography of the breast may be performed to detect the breast cancer associated with Paget's disease of the breast.
MRI
MRI may be performed to detect the breast cancer associated with Paget's disease of the breast.
Other Imaging Findings
Mammogram may be performed to detect the breast cancer associated with Paget's disease of the breast.
Other Diagnostic Studies
No additional tests are recommended for the diagnosis of Paget's disease of the breast.
Treatment
Medical Therapy
The predominant therapy for Paget's disease of the breast is surgical resection. Adjunctive radiation may be required.
Surgery
Mastectomy is the mainstay of treatment for Paget's disease of the breast. Patients who do not have a palpable lump are treated with removal of the nipple and areola, followed by whole-breast radiation therapy, whereas patients with associated ductal carcinoma in situ or invasive breast cancer are treated with complete resection of the underlying disease with excision of the nipple-areola complex and radiation therapy of the remaining breast tissue. When lymph nodes are involved, more extensive axillary lymph node surgery may be needed.
References
- ↑ 1.0 1.1 1.2 Lopes Filho, Lauro Lourival; Lopes, Ione Maria Ribeiro Soares; Lopes, Lauro Rodolpho Soares; Enokihara, Milvia M. S. S.; Michalany, Alexandre Osores; Matsunaga, Nobuo (2015). "Mammary and extramammary Paget's disease". Anais Brasileiros de Dermatologia. 90 (2): 225–231. doi:10.1590/abd1806-4841.20153189. ISSN 1806-4841.
- ↑ 2.0 2.1 Gaspari, Eleonora; Ricci, Aurora; Liberto, Valeria; Scarano, Angela Lia; Fornari, Maria; Simonetti, Giovanni (2013). "An Unusual Case of Mammary Paget's Disease Diagnosed Using Dynamic Contrast-Enhanced MRI". Case Reports in Radiology. 2013: 1–5. doi:10.1155/2013/206235. ISSN 2090-6862.
- ↑ Paget's disease of the breast. U.S. Preventive Services Task Force.http://www.uspreventiveservicestaskforce.org/BrowseRec/Search?s=breast+cancer