Sexcord/ stromal ovarian tumors classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Sexcord/ stromal ovarian tumors may be classified according to WHO into 3 subtypes: Pure stromal tumors, pure sexcord tumors, mixed stromal and sexcord tumors. Histological classification of sexcord-stromal ovarian tumors includes granulosa stromal cell tumors, sertoli leydig cell tumors, gynandroblastoma,

Classification

WHO classification for ovarian sex cord-stromal tumors:[1][2][3][4][5]

  • Pure stromal tumors
    • Fibroma
    • Cellular fibroma
    • Thecoma
    • Luteinized thecoma associated with sclerosing peritonitis
    • Fibrosarcoma
    • Sclerosing stromal tumor
    • Signet-ring stromal tumor
    • Microcystic stromal tumor
    • Leydig cell tumor
    • Steroid cell tumor
    • Steroid cell tumor, malignant
  • Pure sex cord tumors
    • Adult granulosa cell tumor
    • Juvenile granulosa cell tumor
    • Sertoli cell tumor
    • Sex cord tumor with annular tubules
  • Mixed sex cord-stromal tumors
    • Sertoli-Leydig cell tumors
      • Well-differentiated
      • Moderately differentiated with heterologous elements
      • Poorly differentiated with heterologous elements
      • Retiform with heterologous elements
    • Sex cord-stromal tumours, NOS
WHO classification scheme for ovarian sex cord-stromal tumors[1][2][3][4][5]
Types Subtypes
Pure stromal tumors
  • Fibroma
  • Cellular fibroma
  • Thecoma
  • Luteinized thecoma associated with sclerosing peritonitis
  • Fibrosarcoma
  • Sclerosing stromal tumor
  • Signet-ring stromal tumor
  • Microcystic stromal tumor
  • Leydig cell tumor
  • Steroid cell tumor
  • Steroid cell tumor, malignant
Pure sex cord tumors
  • Adult granulosa cell tumor
  • Juvenile granulosa cell tumor
  • Sertoli cell tumor
  • Sex cord tumor with annular tubules
Mixed sex cord-stromal tumors
  • Sertoli-Leydig cell tumors
    • Well-differentiated
    • Moderately differentiated with heterologous elements
    • Poorly differentiated with heterologous elements
    • Retiform with heterologous elements
  • Sex cord-stromal tumours, NOS

NOS, not otherwise specified.

Histological classification of ovarian sex cord‐stromal tumors[6]
Types Subtypes
Granulosa‐stromal cell tumors
  • Granulosa cell tumor
  • Tumors in the thecoma‐fibroma group
    • Thecoma
    • Fibroma
    • Unclassified
Sertoli–Leydig cell tumors
  • Well‐differentiated
    • Sertoli cell tumor
    • Sertoli cell tumor with lipid storage
    • Sertoli–Leydig cell tumor (tubular adenoma with Leydig cells)
  • Of intermediate differentiation
  • Poorly differentiated (sarcomatoid)
  • With heterologous elements
Gynandroblastoma No specific subtypes
Unclassified No specific subtypes

International Agency for Research on Cancer Histologic Groups of Ovarian Tumors Classification from International agency for research on cancer is summarized in the table: [2][7][3]

Ovarian tumors
  • Carcinoma
    • Serous carcinoma
    • Mucinous carcinomac
    • Endometrioid carcinoma
    • Clear cell carcinoma
    • Adenocarcinoma NOS
    • Other specified carcinomas
    • Unspecified carcinoma
  • Sex cord-stromal tumors
  • Germ cell tumors
  • Other specified cancers (including malignant Brenner tumor, mullerian mixed tumor, and carcinosarcoma)
  • Unspecified cancer

References

  1. 1.0 1.1 Horta M, Cunha TM (2015). "Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists". Diagn Interv Radiol. 21 (4): 277–86. doi:10.5152/dir.2015.34414. PMC 4498422. PMID 26054417.
  2. 2.0 2.1 2.2 Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J (April 2016). "The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications". Arch. Gynecol. Obstet. 293 (4): 695–700. doi:10.1007/s00404-016-4035-8. PMID 26894303.
  3. 3.0 3.1 3.2 Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J (October 2015). "Statement by the Kommission Ovar of the AGO: The New FIGO and WHO Classifications of Ovarian, Fallopian Tube and Primary Peritoneal Cancer". Geburtshilfe Frauenheilkd. 75 (10): 1021–1027. doi:10.1055/s-0035-1558079. PMC 4629993. PMID 26556905.
  4. 4.0 4.1 McCluggage WG (August 2011). "Morphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesis". Pathology. 43 (5): 420–32. doi:10.1097/PAT.0b013e328348a6e7. PMID 21716157.
  5. 5.0 5.1 Chen, Vivien W.; Ruiz, Bernardo; Killeen, Jeffrey L.; Cot�, Timothy R.; Wu, Xiao Cheng; Correa, Catherine N.; Howe, Holly L. (2003). "Pathology and classification of ovarian tumors". Cancer. 97 (S10): 2631–2642. doi:10.1002/cncr.11345. ISSN 0008-543X. replacement character in |last4= at position 4 (help)
  6. Fuller, P.J.; Leung, D.; Chu, S. (2017). "Genetics and genomics of ovarian sex cord-stromal tumors". Clinical Genetics. 91 (2): 285–291. doi:10.1111/cge.12917. ISSN 0009-9163.
  7. "onlinelibrary.wiley.com".

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