Radiation proctitis epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Overview

The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
The exact incidence of the radiation proctitis is not available and largely depends on number of factors such as:
the dose of radiation,
area of exposure,
method of delivery,
the use of cytoprotective agents,
dose fraction regimens, and
the interval between sessions.
The incidence rate of radiation proctitis in patients treated with the external beam radiation therapy is estimated to range from 2% to 39%, depending upon the severity and grade of proctitis.^[1]
The incidence rate of radiation proctitis in patients treated with brachytherapy is 8% to 13% when used alone and up to 21% in combination with other modalities.^[2]
Smith et al. reported a 20% incidence of RP with a radiation dose up to 7.500 Cgy and a 60% incidence of RP with doses greater than 7.500 Cgy^[3]

The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
The prevalence of [disease/malignancy] is estimated to be [number] cases annually.
The incidence of chronic radiation proctitis is estimated at 2%–20%^[4]

In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate/mortality rate of [number range]%.
The case-fatality rate/mortality rate of [disease name] is approximately [number range].

Patients of all age groups may develop [disease name].
The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.
[Disease name] commonly affects individuals younger than/older than [number of years] years of age.
[Chronic disease name] is usually first diagnosed among [age group].
[Acute disease name] commonly affects [age group].

There is no racial predilection to [disease name].
[Disease name] usually affects individuals of the [race 1] race. [Race 2] individuals are less likely to develop [disease name].

[Disease name] affects men and women equally.
[Gender 1] are more commonly affected by [disease name] than [gender 2]. The [gender 1] to [gender 2] ratio is approximately [number > 1] to 1.

[Disease name] is a common/rare disease that tends to affect [patient population 1] and [patient population 2].

↑ Beard CJ, Propert KJ, Rieker PP, Clark JA, Kaplan I, Kantoff PW; et al. (1997). "Complications after treatment with external-beam irradiation in early-stage prostate cancer patients: a prospective multiinstitutional outcomes study". J Clin Oncol. 15 (1): 223–9. doi:10.1200/JCO.1997.15.1.223. PMID 8996146.
↑ Zeitlin SI, Sherman J, Raboy A, Lederman G, Albert P (1998). "High dose combination radiotherapy for the treatment of localized prostate cancer". J Urol. 160 (1): 91–5, discussion 95-6. PMID 9628612.
↑ Smit, W.G.J.M.; Helle, P.A.; Van Putten, W.L.J.; Wijnmaalen, A.J.; Seldenrath, J.J.; Van Der Werf-Messing, B.H.P. (1990). "Late radiation damage in prostate cancer patients treated by high dose external radiotherapy in relation to rectal dose". International Journal of Radiation Oncology*Biology*Physics. 18 (1): 23–29. doi:10.1016/0360-3016(90)90262-I. ISSN 0360-3016.
↑ Tagkalidis PP, Tjandra JJ (2001). "Chronic radiation proctitis". ANZ J Surg. 71 (4): 230–7. PMID 11355732.