Radiation proctitis natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
O
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
The symptoms and extent of radiation proctitis are variable and usually develop insidiously.The symptoms depend on the dose and duration of the radiation and how sensitive the bowel is to radiation.
Natural History, Complications and Prognosis
Natural History
- The symptoms and extent of radiation proctitis are variable and usually develop insidiously. The symptoms depend on the dose and duration of the radiation and how sensitive the bowel is to radiation. [1]
- In acute radiation proctitis symptoms usually start shortly after commencement of radiation therapy and progress reaching a peak within 6 weeks.In most cases, the symptoms of acute radiation colitis are self-limiting however upto 20 percent of patients with acute radiation proctitis will have symptoms that are severe enough to require an interruption in radiation treatment.
- The chronic radiation proctitis has delayed onset and symptoms often become noticeable months to years after the completion of radiotherapy. The symptoms may occasionally follow acute radiation colitis. However, previous acute radiation colitis does not increase the risk of a patient developing chronic radiation colitis.Also, absence of acute radiation colitis, does not prevent chronic radiation colitis from occurring. Treatment is required for chronic radiation colitis because resolution of the symptoms is uncommon without intervention
Complications
Common complications of [disease name] include:
- [Complication 1]
- [Complication 2]
- Risk of development of the secondary malignancy"www.gastrojournal.org".
Prognosis
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [--]%.
- Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
References
- ↑ Gilinsky NH, Burns DG, Barbezat GO, Levin W, Myers HS, Marks IN (1983). "The natural history of radiation-induced proctosigmoiditis: an analysis of 88 patients". Q J Med. 52 (205): 40–53. PMID 6603628.