Acinic cell carcinoma differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
Differentiating acinic cell carcinoma from other Diseases
Differentiating acinic cell carcinoma from other diseases on the basis of histology findings
On the basis of histologic findings acinic cell carcinoma must be differentiated from other salivary and head and neck masses such as slivary metastasis of of thyroid carcinoma, salivary oncocytoma, mucoepidermoid carcinoma, inconspicuous mucous/squamoid cells, mammary analogue secretory carcinoma.
| Diseases | Para-clinical findings | Over lapping features | Distinguishing features | |
|---|---|---|---|---|
| slivary metastasis of of thyroid carcinoma | Empty appearance, grooves, pseudoinclusions | Immunohistochemistry (tyrogloubin) | ||
| salivary oncocytoma | Eosinophilic, non-serous cells | Hematoxylin | ||
| mucoepidermoid carcinoma | Microcystic, and follicula, inconspicuous mucous/squamoid cells, eosinophilic | Immunohistochemistry for p63 | ||
| mammary analogue secretory carcinoma | Histologically similar | Lack of PAS-positive secretory granules, vimentin positive, adipophilin positive | ||