Beriberi history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
History and Symptoms
- Cardiovascular or wet beriberi is manifested by cardiac hypertrophy and heart failure with high cardiac output.
- Tachycardia,
- Respiratory distress,
- Edema of the legs
- Severe lactic acidosis.
- Neurological or dry beriberi is manifested by polyneuritis (sometimes paralysis) that typically starts in the lower limbs and progresses to the upper limbs,
- Exaggeration, followed by loss of deep tendon reflexes
- Muscle weakness and muscle pain
- Convulsions.
- Gastrointestinal symptoms are due to delayed gastric emptying and colon dilation.
- Loss of appetite,
- Vague abdominal complaints
- Constipation
- Nausea and vomiting in advanced stages.
- Wernicke-korsakoff syndrome:
- Wernicke's disease is a triad of nystagmus, ophthalmoplegia, and ataxia, along with confusion.
- Korsakoff's psychosis is impaired short-term memory and confabulation with otherwise grossly normal cognition.
- This combination is almost exclusively described in chronic alcoholics with thiamine deficiency.