Analgesic nephropathy diagnostic study of choice
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
Diagnostic Study of Choice
Renal Biopsy
- Renal biopsy is the diagnostic study of choice.[1]
- However, renal biopsy is an invasive procedure and there is risk of complications, therefore CT scan without contrast of the abdomen is usually preferred.[1][2]
- The pathology of classic analgesic nephropathy caused by phenacetin and phenacetin-containing analgesics was caused by capillary sclerosis in the renal medulla due to toxic metabolites of phenacetin which would lead to:[3][4]
- Papillary necrosis
- Tubulointerstitial nephropathy
- Cortical atrophy
References
- ↑ 1.0 1.1 Template:Cite
- ↑ de Broe ME, Elseviers MM (1998). "Analgesic nephropathy". N. Engl. J. Med. 338 (7): 446–52. PMID 9459649. Unknown parameter
|month=ignored (help) - ↑ Mihatsch MJ, Hofer HO, Gudat F, Knüsli C, Torhorst J, Zollinger HU (1983). "Capillary sclerosis of the urinary tract and analgesic nephropathy". Clin Nephrol. 20 (6): 285–301. PMID 6641031.
- ↑ Mihatsch MJ, Khanlari B, Brunner FP (2006). "Obituary to analgesic nephropathy--an autopsy study". Nephrol Dial Transplant. 21 (11): 3139–45. doi:10.1093/ndt/gfl390. PMID 16891638.