C4 glomerulopathy historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]
Overview
Historical Perspective
C4 Nephritic factor (NeF) was first defined in 1980 by Halbwachs at al. C4 nephritic factor (C4NeF) is like C3NeF, this stabilizes the C3-convertase (C4bC2a) commonly used by the lectin and the classical pathway, in a dose-dependent manner.C4NeF was noticed in systemic lupus erythematosus, acute glomerulonephritis, and chronic proliferative glomerulonephritis and was also described in 100 hypocomplementemias MPGN patients with or without C3NeF.Sethi et al. defined C4d+ dominant Dense deposit disease wherein C3 was absent[1][2][3][4].
References
- ↑ Halbwachs L, Leveillé M, Lesavre P, Wattel S, Leibowitch J (1980). "Nephritic factor of the classical pathway of complement: immunoglobulin G autoantibody directed against the classical pathway C3 convetase enzyme". J Clin Invest. 65 (6): 1249–56. doi:10.1172/jci109787. PMC 371461. PMID 6902727.
- ↑ Ohi H, Yasugi T (1994). "Occurrence of C3 nephritic factor and C4 nephritic factor in membranoproliferative glomerulonephritis (MPGN)". Clin Exp Immunol. 95 (2): 316–21. doi:10.1111/j.1365-2249.1994.tb06530.x. PMC 1534915. PMID 8306508.
- ↑ Tanuma Y, Ohi H, Watanabe S, Seki M, Hatano M (1989). "C3 nephritic factor and C4 nephritic factor in the serum of two patients with hypocomplementaemic membranoproliferative glomerulonephritis". Clin Exp Immunol. 76 (1): 82–5. PMC 1541731. PMID 2736802.
- ↑ Daha MR, van Es LA (1980). "Relative resistance of the F-42-stabilized classical pathway C3 convertase to inactivation by C4-binding protein". J Immunol. 125 (5): 2051–4. PMID 6903579.