C4 glomerulopathy screening
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C4 glomerulopathy Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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C4 glomerulopathy screening On the Web |
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American Roentgen Ray Society Images of C4 glomerulopathy screening |
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Risk calculators and risk factors for C4 glomerulopathy screening |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]
Overview
Screening
There is insufficient evidence to recommend routine screening for C4 glomerulopathy. Quantifying CD46 expression on peripheral blood mononuclear cells for mutations and genes that encrypt complement factors include[1][2]:
- CFH
- CFI
- CD46 (encoding CD46)
- CFHR1, CFHR2, CFHR3, CFHR4, and CFHR5
- Genes that encode complement activators
- CFB
- C3
References
- ↑ Zhang Y, Meyer NC, Fervenza FC, Lau W, Keenan A, Cara-Fuentes G; et al. (2017). "C4 Nephritic Factors in C3 Glomerulopathy: A Case Series". Am J Kidney Dis. 70 (6): 834–843. doi:10.1053/j.ajkd.2017.07.004. PMC 5701858. PMID 28838767.
- ↑ Bu F, Borsa NG, Jones MB, Takanami E, Nishimura C, Hauer JJ; et al. (2016). "High-Throughput Genetic Testing for Thrombotic Microangiopathies and C3 Glomerulopathies". J Am Soc Nephrol. 27 (4): 1245–53. doi:10.1681/ASN.2015040385. PMC 4814193. PMID 26283675.