Polycythemia history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2] Zaida Obeidat, M.D.
Overview
The hallmark symptoms of polycythemia vera are headaches, dizziness, erythromelalgia, abdominal fullness due to splenomegaly, etc.
History and Symptoms
- Clinical course is insidious, more commonly it is noticed as an incidental finding on a routine blood test. Patients may present with nonspecific findings like fatigue, headache, dizziness, itchiness, especially after a warm shower. Bloating or "fullness" is also sometimes reported due to marked splenomegaly.
- If adequately managed, the natural course of the disease tends to be long. The cause of death remains unknown in a large majority of cases. Other causes of death include acute leukemia, malignancies secondary to the disease, thrombotic complications, cardiac failure, and natural progression of the disease. [1]
Symptoms
Common symptoms of PV include:[2][3][4]
- Dizziness or vertigo
- Headaches
- Diaphoresis
- Itchiness
- Tinnitus
- Blurred vision
- Fatigue
- Reddish or purplish skin on the palms, earlobes, and nose
- Bleeding or bruising
- Burning sensation in the feet
- Abdominal fullness
- Epistaxis
- Bleeding gums
- Gout
- Budd-Chiari syndrome
- Atypical chest pain
References
- ↑ Büyükaşik Y, Alİ R, Ar C, Turgut M, Yavuz S, Saydam G (August 2018). "Polycythemia vera: diagnosis, clinical course, and current management". Turk J Med Sci. 48 (4): 698–710. doi:10.3906/sag-1806-43. PMID 30114348.
- ↑ Lelonek E, Matusiak Ł, Wróbel T, Szepietowski JC (2018). "Aquagenic Pruritus in Polycythemia Vera: Clinical Characteristics". Acta Derm Venereol. 98 (5): 496–500. doi:10.2340/00015555-2906. PMID 29437189.
- ↑ Saini KS, Patnaik MM, Tefferi A (2010). "Polycythemia vera-associated pruritus and its management". Eur J Clin Invest. 40 (9): 828–34. doi:10.1111/j.1365-2362.2010.02334.x. PMID 20597963.
- ↑ Murphy S (1992). "Polycythemia vera". Dis Mon. 38 (3): 153–212. doi:10.1016/0011-5029(92)90002-7. PMID 1587207.