Acute disseminated encephalomyelitis epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Epidemiology and Demographics
Incidence
- The incidence of acute disseminated encephalomyelitis is about 1 in 125,000-250,000 people each year, in children younger than 10 years, despite the fact that it is a rare disorder.[1][2]
- Each year, regional medical centers in the United States, the United Kingdom, and Australia see three to six instances.[3]
Prevalence
- The prevalance of acute disseminated encephalomyelitis rises as one moves further away from the Equator.[4]Closing
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Case-fatality rate/Mortality rate
- Although acute disseminated encephalomyelitis is potentially lethal, the mortality rate is none to low, but few studies found that mortality was around 3%.[5][6][7][8]
Age
- The usual age of onset is 3 to 7 years, few cases been reported between 10 and twenty.
Gender
- Acute disseminated encephalomyelitis affects males more likely than females (male to female ratio of 1.3:1), and it happens more frequently in the winter and spring.
Race
- There is no racial predilection to the development of acute disseminated encephalomyelitis and affects people all over the world.[9]
Region
- It affects people all over the world, comparable to the geographic distribution of multiple sclerosis.
References
- ↑ Hynson JL, Kornberg AJ, Coleman LT, Shield L, Harvey AS, Kean MJ (2001). "Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children". Neurology. 56 (10): 1308–12. doi:10.1212/wnl.56.10.1308. PMID 11376179.
- ↑ Murthy SN, Faden HS, Cohen ME, Bakshi R (2002). "Acute disseminated encephalomyelitis in children". Pediatrics. 110 (2 Pt 1): e21. doi:10.1542/peds.110.2.e21. PMID 12165620.
- ↑ Dale RC, de Sousa C, Chong WK, Cox TC, Harding B, Neville BG (2000). "Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children". Brain. 123 Pt 12: 2407–22. doi:10.1093/brain/123.12.2407. PMID 11099444.
- ↑ Yamaguchi Y, Torisu H, Kira R, Ishizaki Y, Sakai Y, Sanefuji M; et al. (2016). "A nationwide survey of pediatric acquired demyelinating syndromes in Japan". Neurology. 87 (19): 2006–2015. doi:10.1212/WNL.0000000000003318. PMC 5109945. PMID 27742816.
- ↑ Absoud M, Lim MJ, Chong WK, De Goede CG, Foster K, Gunny R; et al. (2013). "Paediatric acquired demyelinating syndromes: incidence, clinical and magnetic resonance imaging features". Mult Scler. 19 (1): 76–86. doi:10.1177/1352458512445944. PMC 3409874. PMID 22516794.
- ↑ Iype M, Kunju PAM, Saradakutty G, Anish TS, Sreedharan M, Ahamed SM (2017). "Short term outcome of ADEM: Results from a retrospective cohort study from South India". Mult Scler Relat Disord. 18: 128–134. doi:10.1016/j.msard.2017.09.018. PMID 29141794.
- ↑ Hennes EM, Baumann M, Schanda K, Anlar B, Bajer-Kornek B, Blaschek A; et al. (2017). "Prognostic relevance of MOG antibodies in children with an acquired demyelinating syndrome". Neurology. 89 (9): 900–908. doi:10.1212/WNL.0000000000004312. PMID 28768844.
- ↑ Absoud M, Parslow RC, Wassmer E, Hemingway C, Duncan HP, Cummins C; et al. (2011). "Severe acute disseminated encephalomyelitis: a paediatric intensive care population-based study". Mult Scler. 17 (10): 1258–61. doi:10.1177/1352458510382554. PMID 20876155.
- ↑ Pellegrino P, Radice S, Clementi E (2014). "Geoepidemiology of acute disseminated encephalomyelitis". Epidemiology. 25 (6): 928–9. doi:10.1097/EDE.0000000000000176. PMID 25265138.