Adrenal atrophy pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Physiology

The normal physiology of adrenal atrophy can be understood as follows:

Adrenal glands produce hormones that help regulate your metabolism, immune system, blood pressure, response to stress and other essential functions. The glands are composed of two parts:

• The adrenal cortex is the outer region and also the largest part of an adrenal gland. It is divided into three separate zones: zona glomerulosa, zona fasciculata and zona reticularis. Each zone is responsible for producing specific hormones.
• The adrenal medulla is located inside the adrenal cortex in the center of an adrenal gland. It produces “stress hormones,” including epinephrine.

Adrenal Atrophy; source: U.S. National Toxicology Program - available at: https://ntp.niehs.nih.gov/nnl/endocrine/adrenal/cxzatrophy/index.htm