Eczema causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.
Overview
There are several possible causes of eczema, majority of which are genetic in origin. Adverse drug effects also manifest as eczema.
Causes
- Damage from the enzymatic activity of allergens is usually prevented by the body's own protease inhibitors, such as, LEKTI, produced from the gene SPINK5.
- Netherton’s syndrome, a congenital condition presenting with erythroderma, food allergy, hay fever, asthma, and urticaria, results from the mutation of this gene. [1]
- Brain-derived neurotrophic factor (BDNF) and Substance P, are responsible for the pruritic sensation in eczema. [3]
Common Medications with Eczema as the Adverse Drug Effect
- Below is a list of commonly prescribed medications with eczema as the common adverse drug effect (Table 1).
| Medication |
|---|
| Cidofovir |
| Flurbiprofen |
| Olaparib |
| Siltuximab |
| Sorafenib |
| Tiagabine |
References
- ↑ Walley AJ, Chavanas S, Moffatt MF; et al. (2001Mutations in this gene are known to cause). "Gene polymorphism in Netherton and common atopic disease". Nat. Genet. 29 (2): 175–8. doi:10.1038/ng728. PMID 11544479. Check date values in:
|year=(help) - ↑ Palmer, C.N. et al. (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nature Genetics 38(4), 441-6. PMID 16550169
- ↑ "'Blood chemicals link' to eczema -- Scientists have identified two blood chemicals linked to itchy eczema, offering new treatment possibilities". BBC News. 26 August 2007. Retrieved 2007-10-16.