Eczema overview
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American Roentgen Ray Society Images of Eczema |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.
Overview
Eczema is a dermatologic problem manifested as swelling, redness, dryness, and itchiness of the skin. Flaking, cracking, oozing, blistering or bleeding may also occur.
Historical Perspective
It was in the 20th century when eczema came into existence, and later on, concepts on this had evolved including major insights on the nature of the disease.
Classification
Eczema is classified according to location, appearance, or etiology.
Pathophysiology
There are two main theories on the existence of atopic dermatitis, also known as atopic eczema - the inside-out hypothesis, and the outside-in hypothesis.
Causes
Eczema could be due to a genetic problem, or a result of the adverse effect of certain medication.
Differentiating Eczema from other Diseases
Differential diagnoses of eczema include infectious disease, inflammatory disease, immunodeficiency problem, or a nutritional deficiency.
Epidemiology and Demographics
In the United States, eczema has a prevalence of 10.7% in children and 7.2% in adults. Eczema has more predilection in males.
Risk Factors
Risk factors of eczema include family history and FLGgene mutation.
Screening
Hanifin and Rajka criteria are the gold standard for diagnosing eczema. It should satisfy 3 out of 4 major criteria, or 3 out of 23 minor criteria. United Kingdom Working Party diagnostic criteria is another alternative method of diagnosing eczema which requires 1 mandatory criterion and 5 major criteria, and no laboratory testing is needed. To assess the long-term control of this disease, three methods are used, namely the repeated measurement of outcomes, the number of medications used, and the occurrence of flares or remissions.
Natural History, Complications, and Prognosis
Eczema can lead to viral, Bacterial and fungal infections. Psychological problems could also arise brought about by constant itching.
Diagnosis
History and Symptoms
A number of things should be ascertained when diagnosing eczema. A thorough history taking must be done to elicit family history, dietary habits, lifestyle habits, and allergies. If the patient is positive for any of these, this disease can be detected through its clinical manifestations.
Physical Examination
Eczema is a chronic, relapsing dermatologic disease. Patients with eczema have pruritus which is an essential feature of this disease.
Laboratory Findings
Levels of IgE are associated with allergy, aside from parasitic infections, autoimmune diseases, and certain carcinomas.
Other Diagnostic Studies
No particular biomarker is reliable to diagnose eczema. However, the current practice is by using the laboratory levels of IgE, which when elevated, can also be associated with allergy, aside from parasitic infections, autoimmune diseases, and certain carcinomas.
Treatment
Medical Therapy
Topical corticosteroids are the mainline treatment for eczema. Different potencies of steroids are rendered specifically for the severity of eczema. Other drug treatments oftenly used for eczema include topical calcineurin inhibitors,crisaborole, antimicrobials, and antifungals.
Surgery
Surgical treatment is not commonly used as a means of management for eczema.
Primary Prevention
Primary prevention is the most effective means to avoid complications of eczema. This can be achieved by applying emolients on the skin, and consumption of probiotics and prebiotics.
Secondary Prevention
Prevention of further trans-epidermal water loss is the cornerstone of management of eczema. Since dysfunctional skin barriers could lead to water loss, daily replenishment of skin moisture is needed. This can be achieved through different modalities such as emollients, occlusives, and humectants.
Cost-Effectiveness of Therapy
The economic impact of eczema causes a burden to patients suffering from this disease. A recent study showed that an average of $274 ($199 indirect cost, and $75 direct cost) is spent by each patient for eczema.
Social Impact
The quality of life of patients suffering from eczema can be tremendously affected, as the pruritus and consequent scratching can bring about sleep disturbance, daytime fatigue, attention-deficit/hyperactivity disorder, headaches, and stunted growth. Ultimately, patients could develop poor self-esteem, embarrassment, and hence, an overall reduced social life.
Future or Investigational Therapies
More emphasis on genetic studies will be given in the future to unfold the remaining majority of unexplained heritability in eczema. However, the challenge still lies in the economical and computational requirements.