Eczema natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.
Overview
Eczema has regarded as a medical condition with a natural history that occurs consistently. It is characterized as a disease with an early onset, mostly during the childhood period, and remits during the adolescence period. [1] If eczema is left untreated, it can lead to viral, bacterial and fungal infections. Psychological problems could also arise brought about by constant itching.
Eczema Natural History, Complications, and Prognosis
Natural History
- Eczema has regarded as a medical condition with a natural history that occurs consistently.
- It is characterized as a disease with an early onset, mostly during the childhood period, and remits during the adolescence period. [1]
Comorbidities
- Individuals suffering from eczema often have comorbidities like asthma [2], allergic rhinitis [3], contact dermatitis [4], and food allergy [3].
Complications
- Eczema can lead to viral, bacterial and fungal infections.
- Psychological problems could also arise brought about by constant itching.
- Table 1 presents the associated comorbidities and complications of eczema.
Complications | Description |
---|---|
Bacterial Infections | Staphylococcus aureus[5][6] and Methicillin-resistant S. aureus colonization. [7] [8] [9] |
Viral Infections | Eczema herpeticum [10], herpes simplex virus [11], and Molluscum contagiosum [12]. |
Fungal Infections | Tinea [11] |
Psychological | Attention-deficit/Hyperactivity Disorder (ADHD) and speech disorders. [13] [14] |
Prognosis
- Hand eczema has poor prognosis with accounted 44% manifestation of symptoms in a 15-year follow-up study. [15]
- In another study, complete healing was only observed among 19.3% of the patients after a 5-year follow-up. [16]
References
- ↑ 1.0 1.1 Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID https://doi.org/10.1016/j.jaci.2017.09.044 Check
|pmid=
value (help). - ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID https://doi.org/10.4168/aair.2011.3.2.67 Check
|pmid=
value (help). - ↑ 3.0 3.1 Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID https://doi.org/10.1016/S0140-6736(81)92459-4 Check
|pmid=
value (help). - ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID https://doi.org/10.1111/j.1600-0536.1990.tb01595.x Check
|pmid=
value (help). - ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID 10.1016/j.cyto.2014.11.023. doi: 10.1016/j.cyto.2014.11.023. Check
|pmid=
value (help). - ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID 10.2500/aap.2017.38.4005. doi: 10.2500/aap.2017.38.4005. Check
|pmid=
value (help). - ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID 10.1111/j.1365-2133.2008.08905.x. doi: 10.1111/j.1365-2133.2008.08905.x. Check
|pmid=
value (help). - ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID 10.1111/j.1365-2133.2010.09679.x. doi: 10.1111/j.1365-2133.2010.09679.x. Check
|pmid=
value (help). - ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID 10.1007/s12016-016-8548-5. doi: 10.1007/s12016-016-8548-5. Check
|pmid=
value (help). - ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID 10.1038/sj.jid.5700657. doi: 10.1038/sj.jid.5700657. Check
|pmid=
value (help). - ↑ 11.0 11.1 Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID 10.3390/jcm4050884. doi: 10.3390/jcm4050884. Check
|pmid=
value (help). - ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID http://dx.doi.org/10.1016/j.cpha.2016.06.004. Check
|pmid=
value (help). - ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID 10.1111/bjd.14697. doi: 10.1111/bjd.14697. Check
|pmid=
value (help). - ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID 10.1016/j.jpeds.2015.09.066. doi: 10.1016/j.jpeds.2015.09.066. Check
|pmid=
value (help). - ↑ Meding B, Wrangsjö K, Järvholm B (2005). "Fifteen-year follow-up of hand eczema: persistence and consequences". Br J Dermatol. 152 (5): 975–80. doi:10.1111/j.1365-2133.2005.06494.x. PMID 15888155.
- ↑ Olesen CM, Agner T, Ebbehøj NE, Carøe TK (2019). "Factors influencing prognosis for occupational hand eczema: new trends". Br J Dermatol. 181 (6): 1280–1286. doi:10.1111/bjd.17870. PMID 30851194.