Thrombosis causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editors-in-Chief: Ujjwal Rastogi, MBBS [2]
Etiology
Rudolf Virchow noted several factors affecting the clot formation, which are:
1).Alterations in blood flow (stasis) : Normally the blood flow throughout the circulatory system, without significantly stopping or slowing any where. In certain pathological conditions where the blood flow slows down or stops, which causes
- a) Increases platelet/endothelium contact
- b) Decrease the dilution of clotting factors
This increases the risk of clot formation and form microthrombi, which further grow and propagate.
2).Injury to the vascular endothelium : Intrinsic or secondary to external trauma(for example in catheterization) can cause intimal damage and can stimulate the clot formation.
3).Alterations in the constitution of blood (hypercoagulability) :This lead to the tendency to develop blood clots(Thrombosis).
These three conditions are collectively known as Virchow's triad.
High altitude has also been known to induce thrombosis [1]. Occasionally, abnormalities in coagulation are to blame.
Intravascular coagulation follows, forming a structureless mass of red blood cells, leukocytes, and fibrin.
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References
- ↑ Kuipers S, Cannegieter SC, Middeldorp S, Robyn L, Büller HR, Rosendaal FR (2007). "The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations". PLoS Med. 4 (9): e290. doi:10.1371/journal.pmed.0040290. PMC 1989755. PMID 17896862.
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