Guillain-Barré syndrome historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, MBBS [2]
Overview
Guillain-Barré syndrome (GBS) is an acute, autoimmune, polyradiculoneuropathy affecting the peripheral nervous system, usually triggered by an acute infectious process. It was first reported by Landry in 1859 as a case study of 10 patients with ascending paralysis. Later the characteristic features of the disease like flaccid paralysis, areflexia and CSF findings were reported by Guillain, Barré, and Strohl. The syndrome was later named Guillain-Barré syndrome.
Historical perspective
- The disease was first described by the French physician Jean Landry in 1859.
- In 1916, Georges Guillain, Jean Alexandre Barré and Andre Strohl diagnosed two soldiers with motor weakness, areflexia and a the key diagnostic abnormality of increased spinal fluid protein production, but normal cell count.[1]. Later, it was called Guillain-Barré syndrome after them.
- GBS is also known as acute inflammatory demyelinating polyneuropathy, acute idiopathic polyradiculoneuritis, acute idiopathic polyneuritis, French Polio and Landry's ascending paralysis.