Acenocoumarol

Acenocoumarol

Clinical data
Routes of administration	Oral
ATC code	B01AA07 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	8 to 11 hours
Identifiers
IUPAC name 2-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-4H- chromen-4-one
CAS Number	152-72-7
PubChem CID	9052
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C19H15NO6
Molar mass	353.326 g/mol

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Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin).

It is a derivative of coumarin and is marketed under the brand names Sintrom and Sinthrome®.

External links

• Template:DiseasesDB
• Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol". Blood Coagul Fibrinolysis. 15 (8): 673–6. PMID 15613922.CS1 maint: Multiple names: authors list (link)
• Lengyel M (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil. 145 (52): 2619–21. PMID 15724697.
• Ufer M (2005). "Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol". Clin Pharmacokinet. 44 (12): 1227–46. PMID 16372822.
• Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients". Br J Haematol. 133 (2): 183–7. PMID 16611310.CS1 maint: Multiple names: authors list (link)