Ticlopidine
Clinical data | |
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Pregnancy category | |
Routes of administration | Oral |
ATC code | |
Pharmacokinetic data | |
Bioavailability | >80% |
Protein binding | 98% |
Metabolism | Hepatic |
Elimination half-life |
|
Excretion | Renal and fecal |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank | |
E number | {{#property:P628}} |
ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
Chemical and physical data | |
Formula | C14H14ClNS |
Molar mass | 263.786 g/mol |
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Overview
Ticlopidine (trade name Ticlid) is an antiplatelet drug in the thienopyridine family. Like clopidogrel, it is an adenosine diphosphate (ADP) receptor inhibitor. It is used in patients in whom aspirin is not tolerated, or in whom dual antiplatelet therapy is desirable. Because it has been reported to increase the risk of thrombotic thrombocytopenic purpura (TTP) and neutropenia, its use has largely been supplanted by the newer drug, clopidogrel, which is felt to have a much lower hematologic risk. The usual dose is 250mg twice daily by the oral route.
Action
- Inihibits platelet aggregation by altering the function of platelet membranes.
- Prolongs bleeding time.
- Decreased incidence of stroke in high-risk patients.
Contraindications
- Hypersensitivity
- Bleeding disorders
- Active bleeding
- Severe liver disease
Precautions
- Risk of bleeding (trauma, surgery, history of peptic ulcer disease)
- Renal or hepatic impairment
- Geriatric patients (increased sensitivity)
- Pregnancy, lactation, or children under 18
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