Thoracic aortic aneurysm causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]
Overview
Two of the most common causes of thoracic aorta aneurysm are Marfan's syndrome and atherosclerosis. In some centers, a prior history of dissection with aneurysmal dilation is the most common cause of surgical repair.
Causes
Common Causes
- Marfan's Syndrome
- Atherosclerosis
- Previous injury to the aorta such as an aortic dissection is the most common cause of aortic aneurysm repair in some institutions
Sporadic Causes
- Ankylosing spondylitis
- Atherosclerosis
- Bacterial infection, often following valvular endocarditis
- Behcet's disease
- Giant cell arteritis
- Previous injury to the aorta such as an aortic dissection
- Syphilis
- Takayasu's arteritis
- Traumatic - Sudden deceleration
Familial Causes
- Familial thoracic aortic aneurysms and dissections
- Bicuspid aortic valve with post-stenotic dilation due to turbulence
Syndromic Causes
- Aortic root dilation with or without associated aortic regurgitation occurs in 75%-80% of Marfan's patients
Causes of Thoracic Aortic Aneurysm by Organ System
Cardiovascular | No underlying causes |
Chemical / poisoning | No underlying causes |
Dermatologic | No underlying causes |
Drug Side Effect | No underlying causes |
Ear Nose Throat | No underlying causes |
Endocrine | No underlying causes |
Environmental | No underlying causes |
Gastroenterologic | No underlying causes |
Genetic | No underlying causes |
Hematologic | No underlying causes |
Iatrogenic | No underlying causes |
Infectious Disease | No underlying causes |
Musculoskeletal / Ortho | No underlying causes |
Neurologic | No underlying causes |
Nutritional / Metabolic | No underlying causes |
Obstetric/Gynecologic | No underlying causes |
Oncologic | No underlying causes |
Opthalmologic | No underlying causes |
Overdose / Toxicity | No underlying causes |
Psychiatric | No underlying causes |
Pulmonary | No underlying causes |
Renal / Electrolyte | No underlying causes |
Rheum / Immune / Allergy | No underlying causes |
Sexual | No underlying causes |
Trauma | No underlying causes |
Urologic | No underlying causes |
Miscellaneous | No underlying causes |
Causes in Alphabetical Order
- Ankylosing spondylitis
- Atherosclerosis
- Bacterial infection, often following valvular endocarditis
- Behcet's disease
- Bicuspid aortic valve with post-stenotic dilation due to turbulence
- Ehlers-Danlos syndrome
- Familial thoracic aortic aneurysms and dissections
- Giant cell arteritis
- Loeys-Dietz syndrome
- Marfan's syndrome
- Previous injury to the aorta such as an aortic dissection
- Syphilis
- Takayasu's arteritis
- Traumatic - Sudden deceleration
- Turner's syndrome