Guillain-Barré syndrome epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, MBBS [2]

Overview

Guillain-Barré syndrome (GBS) is an acute, autoimmune, polyradiculoneuropathy affecting the peripheral nervous system, usually triggered by an acute infectious process. The incidence is approximately 1.2 - 3 / 100,000 persons per year across the world. It is commoner in males compared to female and has two peaks (15-35 years and 50-75 years). Incidence is similar across different races.

Epidemiology and Demographics

USA

It is the commonest cause of acute, flaccid paralysis in USA.
Incidence- 1.2 - 3 / 100,000 persons ^[1], ^[2]

International

It has been reported all over the world.
The incidence is around 1.5 - 3 / 100,000 persons
The antecedence of Campylobacter jejuni is commoner in Japan and other Asian countries. Whereas, in American continents and European nations an antecedence of cytomegalovirus is common.

Age

Incidence increases with age.
Bimodal distribution - First peak during 15 - 35 yrs and second during old age ^[3].
New-borns and infants have the least risks of development of GBS

Races

Incidence is similar across different races.

Gender

It occurs more commonly in males compared to females. Male to female ratio 1.5:1
The incidence has been found to increase post-partum and decreases during pregnancy ^[4]

References

↑ Day N (1991). "AIDS and insurer discretion". Ohio Medicine : Journal of the Ohio State Medical Association. 87 (5): 226. PMID 1741839. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)
↑ Romhányi I (1975). "[Letter: The concept of "caucasian race"]". Orvosi Hetilap (in Hungarian). 116 (41): 2449. PMID 1187127. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)
↑ Prevots DR, Sutter RW (1997). "Assessment of Guillain-Barré syndrome mortality and morbidity in the United States: implications for acute flaccid paralysis surveillance". The Journal of Infectious Diseases. 175 Suppl 1: S151–5. PMID 9203708. Retrieved 2012-02-17. Unknown parameter |month= ignored (help)
↑ Jiang GX, de Pedro-Cuesta J, Strigård K, Olsson T, Link H (1996). "Pregnancy and Guillain-Barré syndrome: a nationwide register cohort study". Neuroepidemiology. 15 (4): 192–200. PMID 8817501. |access-date= requires |url= (help)

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[pmid1741839-1] Day N (1991). "AIDS and insurer discretion". Ohio Medicine : Journal of the Ohio State Medical Association. 87 (5): 226. PMID 1741839. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)

[pmid1187127-2] Romhányi I (1975). "[Letter: The concept of "caucasian race"]". Orvosi Hetilap (in Hungarian). 116 (41): 2449. PMID 1187127. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)

[pmid9203708-3] Prevots DR, Sutter RW (1997). "Assessment of Guillain-Barré syndrome mortality and morbidity in the United States: implications for acute flaccid paralysis surveillance". The Journal of Infectious Diseases. 175 Suppl 1: S151–5. PMID 9203708. Retrieved 2012-02-17. Unknown parameter |month= ignored (help)

[pmid8817501-4] Jiang GX, de Pedro-Cuesta J, Strigård K, Olsson T, Link H (1996). "Pregnancy and Guillain-Barré syndrome: a nationwide register cohort study". Neuroepidemiology. 15 (4): 192–200. PMID 8817501. |access-date= requires |url= (help)

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