Ebola medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

A hospital isolation ward in Gulu, Uganda during the October 2000 outbreak

Treatment is primarily supportive and includes:

• Minimizing invasive procedures
• Balancing electrolytes since patients are frequently dehydrated
• Replacing lost coagulation factors to help stop bleeding
• Maintaining oxygen and blood levels
• Treating any complicating infections.

Convalescent Plasma (factors from those who have survived Ebola infection) shows promise as a treatment for the disease. Ribavirin is ineffective. Interferon is also thought to be ineffective. In monkeys, administration of an inhibitor of coagulation (rNAPc2) has shown some benefit, protecting 33% of infected animals from a usually 100% (for monkeys) lethal infection (unfortunately this inoculation does not work on humans). In early 2006, scientists at USAMRIID announced a 75% recovery rate after infecting four rhesus monkeys with Ebola virus and administering antisense drugs.