Dyspepsia historical perspective

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Historical Perspective

Indigestion is an old English word meaning ‘lack of digestion’, and dyspepsia symptoms have been recognized since the birth of medicine. However, the underlying pathogenesis of dyspepsia only began to be appreciated when Baillie in 1799 first described the anatomy and symptoms of gastric ulcer disease.

Development of barium X-ray radiology by Cannon in 1897 led to the clinical recognition of peptic ulcer disease and its relationship with symptoms.

Walter Alvarez at the Mayo Clinic in Rochester, MN was the first to apply the term 'functional dyspepsia' in 1916 to describe patients with ulcer-like symptoms and a normal X-ray.