Sodium valproate
 | |
| Clinical data | |
|---|---|
| Pregnancy category | |
| Routes of administration | Oral, i.v. |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Protein binding | 90–95% |
| Metabolism | 75% by CYP enzymes |
| Elimination half-life | 9–18 hours |
| Excretion | 20% excreted as glucuronide |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C8H15NaO2 |
| Molar mass | 166.20 g/mol |
Sodium valproate (INN) or valproate sodium (USAN) is the sodium salt of valproic acid and is an anticonvulsant used in the treatment of epilepsy and bipolar disorder, as well as other psychiatric conditions requiring the administration of a mood stabilizer. The intravenous formulations are used when oral administration is not possible.
Formulations
Trade names are in bold, followed by the manufacturer.
U.S.
- Intravenous injection – Depacon by Abbott Laboratories.
- Syrup – Depakene by Abbott Laboratories. (Note Depakene capsules are valproic acid).
UK and Australia
- Tablets – Orlept by Wockhardt and Epilim by Sanofi-Aventis.
- Oral solution – Orlept Sugar Free by Wockhardt and Epilim by Sanofi-Aventis.
- Syrup – Epilim by Sanofi-Aventis.
- Intravenous injection – Epilim Intravenous by Sanofi-Aventis.
- Extended release tablets – Epilim Chrono by Sanofi-Aventis. A combination of sodium valproate and valproic acid in a 2.3:1 ratio.
- Enteric-coated tablets – Epilim EC200 by Sanofi-synthélabo. A 200 mg sodium valproate enteric-coated tablet.
Germany, Switzerland, Norway
- Tablets – Orfiril by Desitin Pharmaceuticals
- Intravenous injection – Orfiril IV by Desitin Pharmaceuticals
South Africa
- Syrup – Convulex by Byk Madaus
Canada
- Intravenous injection – Epival or Epiject by Abbott Laboratories.
- Syrup – Depakene by Abbott Laboratories. Generic formulations include Apo-Valproic and ratio-Valproic.
Others
In much of Europe, Depakine and Depakine Chrono are equivalent to Epilim and Epilim Chrono above.
See also
External links
Categories:
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- Anticonvulsants
- Mood stabilizers
- Teratogens