Group B streptococcal infection medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]
Overview
Medical Therapy in Meningitis
Empirical Antibiotic Therapy in Neonatal Meningitis
GBS should be suspected as a causative agent for bacterial meningitis in infants less than two years of age for whom empirical antibiotic therapy should be initiated immediately.
Age | Possible pathogens causing the bacterial meningitis | Empirical treatment |
< 1 month | Streptococcus agalactiae Escherichia coli Listeria monocytogenes Klebsiella |
Ampicillin + cefotaxime OR Ampicillin + aminoglycoside |
1-23 months | Streptococcus pneumoniae Neisseria meningitidis Streptococcus agalactiae Haemophilus influenzae E. coli |
Vancomycin + third generation cephalosporin |
Targeted Antibiotic Therapy in Neonatal Meningitis
Recommended therapy for GBS meningitis | Alternative therapy for GBS meningitis |
Ampicillin OR Penicillin Consider adding an aminoglycoside |
Third generation cephalosporin (Ceftriaxone or cefotaxime) |
Recommended Dosage of Antibiotics
Antibiotic agent | Dosage |
Ampicillin | 0-7 days: 150 mg/kg 8-28 days: 200 mg/kg Infants > 28 days: 300 mg/kg |
Cefotaxime | |
Ceftriaxone | |
Gentamicin | |
Amikacin | |
[[Tobramycin | |
Penicillin | |
Vancomycin | |
Ceftriaxone | |
Ceftazidime |