Endometrial cancer classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Endometrial cancer may be classified into 7 subtypes based on histology.

Classification

• Endometrial cancers are classified in one of the following two categories:

• Type 1 may arise from complex atypical hyperplasia and is pathogenetically linked to unopposed estrogenic stimulation.
• Type 2 develops from atrophic endometrium and is not linked to hormonally driven pathogenesis.

Cellular Classification of Endometrial Cancer

1. Endometrioid (75%–80%).[The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant glandular epithelial elements]

• Ciliated adenocarcinoma.
• Secretory adenocarcinoma.
• Papillary or villoglandular.
• Adenocarcinoma with squamous differentiation.

• Adenoacanthoma.
• Adenosquamous.[Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium]

2. Uterine papillary serous (<10%).

3. Mucinous (1%).

4. Clear cell (4%).

5. Squamous cell (<1%).

6. Mixed (10%).

7. Undifferentiated

• 

  Endometrial stromal sarcoma

• 

  Malignant mixed müllerian tumor

References

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