Glioblastoma multiforme pathophysiology

Glioblastoma multiforme Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Pathophysiology

Microscopic Pathology

• 
  Glioblastoma (histology slide)

Genetics

• Almost all cases of GBM are sporadic, without a familial predilection, although chromosomal aberrations such as PTEN mutation, and p53 mutation are commonly seen in these tumors.
• Growth factor aberrant signaling associated with EGFR, and PDGF are also seen.

References

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