Glioblastoma multiforme pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Pathophysiology

Genetics

• Development of glioblastoma is the result from multiple genetic mutations.
• Genes involved in the pathogenesis of primary glioblastoma include:
  • Mdm2
  • PTEN
  • Chromosome 10p

• Genes involved in the pathogenesis of secondary glioblastoma include:
  • IDH1
  • p53
  • Chromosomes 10q, 17p, and 19q

Associated Conditions

Glioblastoma may be associated with:

• Neurofibromatosis type 1
• Li-Fraumeni syndrome
• Turcot syndrome
• Ollier disease
• Maffucci syndrome

Microscopic Pathology

• 
  Glioblastoma (histology slide)

References

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