Nasopharyngeal carcinoma pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]

Overview

On microscopic histopathological analysis, abundant dense eosinophilic cytoplasm and prominent lymphoid component are characteristic findings of nasopharyngeal carcinoma.

Features:^[2]

Prominent lymphoid component - key feature.
Features of squamous cell carcinoma:
- Cohesive cells with:
  - Abundant dense eosinophilic cytoplasm.
  - Central nuclei +/- small/indistinct nucleoli.

World Health Classification (2005) for NPC:^[2]

Type	Histology	Description	EBV	Prevalence	Prognosis
1	Keratinizing SCC	graded poorly-well-diff.	-ve		bad
2a	Nonkeratinizing carcinoma, differentiated	well defined cell borders & tumour nest borders	+ve		good
2b	Nonkeratinizing carcinoma, undifferentiated	sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm		most common
3	Basaloid SCC	mimics basal cell carcinoma		least common

↑ Abdel Khalek Abdel Razek, A.; King, A. (2012). "MRI and CT of nasopharyngeal carcinoma". AJR Am J Roentgenol. 198 (1): 11–8. doi:10.2214/AJR.11.6954. PMID 22194474. Unknown parameter |month= ignored (help)
↑ ^2.0 ^2.1 Nasopharyngeal carcinoma http://librepathology.org/wiki/index.php/Nasopharyngeal_carcinoma
↑ Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J (1998). "Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product". Am. J. Pathol. 152 (4): 865–9. PMC 1858242. PMID 9546345. Unknown parameter |month= ignored (help)