Glioblastoma multiforme surgery
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Glioblastoma multiforme Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Surgery is the mainstay of treatment for glioblastoma multiforme.[1]
Surgery
1. Surgery is the mainstay of treatment for glioblastoma multiforme.[1]
- The aim of surgery is to:
- Make a definitive diagnosis
- Debulk the tumor to relieve elevated intracranial pressure
- Reduce the tumor mass as a precursor to adjuvant treatment
- Removal of 98% or more of the tumor has been associated with a better prognosis
- The chances of near-complete initial removal of the tumor can be greatly increased if the surgery is guided by a fluorescent dye known as 5-aminolevulinic acid.
- Glioblastoma multiforme tumor cells are widely infiltrative through the brain at diagnosis. Despite a near-total resection, majority of people with glioblastoma multiforme develop recurrence, either at the original site or at distant satellite lesions within the brain.
2. CSF shunting is performed to relieve the pressure in the brain due to blockade in the flow of cerebrospinal fluid by the tumor.
- External ventricular drain
- Temporary shunt
- Internal drain
- Permanent shunt
- Drains CSF into the patient’s abdomen, where it is absorbed into the body
References
- ↑ 1.0 1.1 Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma