Insulinoma epidemiology and demographics
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Epidemiology
- Insulinomas are rare neuroendocrine tumors with an incidence estimated at 1 to 4 new cases per million persons per year.
- Insulinoma is one of the most common types of tumor arising from the islets of Langerhans cells (pancreatic endocrine tumors).
- Estimates of malignancy (metastases) range from 5% to 30%.
- Over 99% of insulinomas originate in the pancreas, with rare cases from ectopic pancreatic tissue.
- About 5% of cases are associated with tumors of the parathyroid glands and the pituitary (Multiple endocrine neoplasia type 1) and are more likely to be multiple and malignant.
- Most insulinomas are small, less than 2 cm.
- The median age at diagnosis is 47 years.
- Females are more commonly affected with insulinoma than males. The male to female ratio is approximately 2 to 3.
- There is no racial predilection to the insulinoma.