Endometrial cancer medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The optimal therapy for endometrial cancer depends on the stage at diagnosis. A combination of chemotherapy and radiation therapy is indicated in stages IIIB- IV.
Medical Therapy
Stage I Endometrial Cancer[1]
- Standard treatment options:
- A total hysterectomy and bilateral salpingo-oophorectomy should be done.
- Selected pelvic lymph nodes may be removed. If they are negative, no postoperative treatment is indicated. Postoperative treatment with a vaginal cylinder is advocated by some clinicians.
Stage II Endometrial Cancer[2]
- Standard treatment options:
- If cervical involvement is documented, options include radical hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic lymph node dissection.
- If the cervix is clinically uninvolved but extension to the cervix is documented on postoperative pathology, radiation therapy should be considered.
Stage III Endometrial cancer[3]
- Standard treatment options:
- Patients with stage III endometrial cancer are treated with surgery, followed by chemotherapy, or radiation therapy, or both.
- Patients with inoperable disease caused by tumor that extends to the pelvic wall may be treated with a combination of chemotherapy and radiation therapy. The usual approach is to use a combination of intracavitary radiation therapy and external-beam radiation therapy.
Stage IV Endometrial cancer[4]
- Standard treatment options:
- Treatment of patients with stage IV endometrial cancer is dictated by the site of metastatic disease and symptoms related to disease sites. For bulky pelvic disease, radiation therapy consisting of a combination of intracavitary and external-beam radiation therapy is used.
References
- ↑ Endometrial Cancer Treatment. National Cancer Institute http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_40 Accessed on September, 7 2015
- ↑ Endometrial Cancer Treatment. National Cancer Institute http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_45 Accessed on September, 7 2015
- ↑ Endometrial Cancer Treatment. National Cancer Institute http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_54 Accessed on September, 7 2015
- ↑ Endometrial Cancer Treatment. National Cancer Institute http://www.cancer.gov/types/uterine/hp/endometrial-treatment-pdq#section/_59 Accessed on September, 7 2015