Gliomatosis cerebri natural history, complications, and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

If left untreated, patients with meningioma may progress to develop focal neurological deficits, altered mental status, hydrocephalus, brain herniation, and ultimately death.
Transformation into glioblastoma (grade 4) may occur a few years later.^[1]

Common complications of gliomatosis cerebri include:^[1]

Prognosis of gliomatosis cerebri is generally poor, and the 5-year survival rate of patients with treatment is approximately 17.7%.^[2]^[3]

The median survival time of gliomatosis cerebri is 14 months.^[4]

The prognosis of gliomatosis cerebri depends on the following:^[5]

Resectibility of the tumor mass
Age of the patient
- Age < 10 year is associated with worse prognosis
Gender of the patient
- Males are associated with a better prognosis than females
Predominant type of cell
- Oligodendroglial cell type of gliomatosis cerebri have a better prognosis
Location of tumor
- Infratentorial tumor is associated with shorter survival.^[4]
Size of the tumor
Stage of the cancer
Primary diagnosis vs. recurrence

↑ ^1.0 ^1.1 Treatment and prognosis of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri
↑ Inoue T, Kumabe T, Kanamori M, Sonoda Y, Watanabe M, Tominaga T (2010). "Prognostic factors for patients with gliomatosis cerebri: retrospective analysis of 17 consecutive cases". Neurosurg Rev. 34 (2): 197–208. doi:10.1007/s10143-010-0306-1. PMID 21301914.
↑ Ross IB, Robitaille Y, Villemure JG, Tampieri D (1991). "Diagnosis and management of gliomatosis cerebri: recent trends". Surg Neurol. 36 (6): 431–40. PMID 1759182.
↑ ^4.0 ^4.1 Herrlinger U, Felsberg J, Küker W, Bornemann A, Plasswilm L, Knobbe CB; et al. (2002). "Gliomatosis cerebri: molecular pathology and clinical course". Ann Neurol. 52 (4): 390–9. doi:10.1002/ana.10297. PMID 12325066.
↑ Brandão RA, de Carvalho GT, de Azeredo Coutinho CA, Christo PP, Santiago CF, Santos Mdo C; et al. (2011). "Gliomatosis cerebri: diagnostic considerations in three cases". Neurol India. 59 (1): 122–5. doi:10.4103/0028-3886.76892. PMID 21339680.