Insulinoma epidemiology and demographics
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
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Overview
The incidence of insulinoma is approximately 0.1 to 0.4 per 100,000 individuals worldwide. There is no racial predilection to the insulinoma. Females are more commonly affected with insulinoma than males.[1] The male to female ratio is approximately 2 to 3. The median age at diagnosis is 45.5 years.[1]
Epidemiology and Demographics
Incidence
- Insulinomas are rare neuroendocrine tumors with an incidence estimated at 1 to 4 new cases per million persons per year. *Insulinoma is one of the most common types of tumor arising from the islets of Langerhans cells (pancreatic endocrine tumors). *Estimates of malignancy (metastases) range from 5% to 30%.
- Over 99% of insulinomas originate in the pancreas, with rare cases from ectopic pancreatic tissue.
- About 5% of cases are associated with tumors of the parathyroid glands and the pituitary (Multiple endocrine neoplasia type 1) and are more likely to be multiple and malignant.
- Most insulinomas are small, less than 2 cm.
Age
- The median age at diagnosis is 45.5 years.[1]
Gender
- Females are more commonly affected with insulinoma than males.[1]
- The male to female ratio is approximately 2 to 3.
Race
- There is no racial predilection to the insulinoma.