Insulinoma epidemiology and demographics
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
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Overview
The incidence of insulinoma is approximately 0.1 to 0.4 per 100,000 individuals worldwide. Females are more commonly affected with insulinoma than males.[1] The male to female ratio is approximately 2 to 3. The median age at diagnosis is 45.5 years.[1] There is no racial predilection to the insulinoma.
Epidemiology and Demographics
Incidence
- Insulinomas are rare neuroendocrine tumors with an incidence estimated at 1 to 4 new cases per million persons per year.
- Insulinoma is one of the most common types of tumor arising from the islets of Langerhans cells (pancreatic endocrine tumors).
- Estimates of malignancy (metastases) range from 5% to 30%.
- Over 99% of insulinomas originate in the pancreas, with rare cases from ectopic pancreatic tissue.
- About 5% of cases are associated with tumors of the parathyroid glands, pituitary, or multiple endocrine neoplasia type 1 and are more likely to be multiple and malignant.
- Most insulinomas are small, less than 2 cm.
Age
- The median age at diagnosis is 45.5 years.[1]
Gender
- Females are more commonly affected with insulinoma than males.[1]
- The female to male ratio is approximately 1.5 to 1.
Race
- There is no racial predilection to the insulinoma.