Hypopharyngeal cancer pathophysiology
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Hypopharyngeal cancer Microchapters |
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Hypopharyngeal cancer pathophysiology On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
Genes involved in the pathogenesis of hypopharyngeal cancer include p16, NOTCH1, cyclin D1, and TP53. Hypopharyngeal cancer is associated with sideropenic dysphagia and Paterson Brown Kelly syndrome.On gross pathology, flattened plaques, mucosal ulceration, and raised margins of the lesion are characteristic findings of hypopharyngeal cancer. On microscopic histopathological analysis, spindle cells, basaloid cells, and nuclear atypia are characteristic findings of hypopharyngeal cancer.[1]
Pathophysiology
Genetics
Genes involved in the pathogenesis of hypopharyngeal cancer include:
Associated Diseases
Hypopharyngeal carcinoma is associated with:[1]
Gross Pathology
On gross pathology, hypopharyngeal cancer is characterized by:[1]
- Flattened plaques
- Raised margins of the lesion
- Mucosal ulceration
- Tumor spread to piriform sinus
Microscopic Pathology
On microscopic histopathological analysis, hypopharyngeal carcinoma is characterized by:[1]
- Spindle cells
- Basaloid cells
- Nuclear atypia
- Abundant chromatin