Uveal melanoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Uveal melanoma may be classified according to Callender classification into four subtypes based on cell type.

Classification

Uveal melanomas originate from melanocytes in the uveal tract. According to the revised Callender classification there are four distinct cellular types.

• Spindle-A cells (spindle-shaped cells with slender nuclei and lacking visible nucleoli).
• Spindle-B cells (spindle-shaped cells with larger nuclei and distinct nucleoli).
• Epithelioid cells (larger polygonal cells with one or more prominent nucleoli).
• Intermediate cells (similar to but smaller than epithelioid cells).

Most primary intraocular melanomas contain variable proportions of epithelioid, spindle-A, and spindle-B cells (mixed-cell melanomas). Pure epithelioid-cell primary melanomas are infrequent (approximately 3% of cases). In the Collaborative Ocular Melanoma Study, mixed-cell type melanomas predominated (86% of cases).