Uveal melanoma MRI

Uveal melanoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Uveal melanoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X Ray
Echocardiography and Ultrasound
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Uveal melanoma MRI On the Web
Most recent articles
cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Uveal melanoma MRI All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Uveal melanoma MRI
CDC on Uveal melanoma MRI
Uveal melanoma MRI in the news
Blogs on Uveal melanoma MRI
to Hospitals Treating Uveal melanoma
Risk calculators and risk factors for Uveal melanoma MRI

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Head and neck MRI may be helpful in the diagnosis of uveal melanoma. Head and neck MRI scan is diagnostic of uveal melanoma. On head and neck MRI, uveal melanoma is characterized by isointense to hypointense mass on T1-weighted MRI and hyperintense mass on T2-weighted MRI.

MRI

MRI is the modality of choice for assessment of malignant uveal melanomas 5-6.

T1 or PD uveal melanomas are seen as moderately high signal mass lesion associated exudative retinal detachment is moderately high signal T2 moderately low signal mass lesion associated exudative retinal detachment is moderately high signal haemorrhagic subretinal fluid has variable signal pattern T1 C+ (Gd) tumours enhance fat suppression useful in detecting extraocular extention

MRI is the modality of choice for pre-treatment staging on retinoblastoma.

• The MRI features of retinoblastoma include:

MRI component	Features
T1	Intermediate signal intensity, hyperintense c.f. vitreous
T2	Hypointense c.f. vitreous
T1 contrast with gadolinium	The mass usually enhances relatively homogeneously when small Larger tumors often have areas of necrosis, rendering it heterogeneous Linear enhancement of the choroid beyond the margins of the tumour should raise the possibility of choroidal involvement, although inflammation may lead to similar appearance Enhancement of the anterior chamber need not represent tumour involvement, with hyperaemia, uveitis and iris neovascularisation all leading to asymmetric enhancement Careful assessment of the optic disc and optic nerve should be carried out to assess for involvement Extra-ocular extension through the sclera will be visible as interruption of the otherwise hypointense non-enhancing sclera by enhancing tumour
Diffusion Weighted Imaging	The tumour shows restricted diffusion on DWI at high b values. It exhibits low ADC values in contrast to the high intensity of the vitreous in the ADC maps ADC map can be used to differentiate viable and necrotic tumour DWI is valuable in evaluating the response to eye-preservation treatment