Cholangiocarcinoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Classification

Cholangiocarcinoma may be classified according to location of the tumor into 3 subtypes:

• Extrahepatic bile duct cancer
• Perihilar bile duct cancer
• Intrahepatic bile duct cancer

Cellular Classification of Cholangiocarcinoma

Extrahepatic Bile Duct Cancer

• Carcinoma in situ
• Adenocarcinoma, not otherwise specified (NOS)
• Adenocarcinoma

• Intestinal type
• Mucinous type
• Clear cell type

• Signet-ring cell carcinoma
• Adenosquamous carcinoma
• Squamous cell carcinoma
• Small cell (oat cell) carcinoma
• Undifferentiated carcinoma

• Spindle cell type
• Giant cell type
• Small cell type

• Papillomatosis
• Papillary carcinoma

• Noninvasive

• Papillary carcinoma

  Invasive

• Carcinoma, NOS

Perihilar Bile Duct Cancer The histologic types include the following:

• Carcinoma in situ
• Adenocarcinoma, not otherwise specified (NOS)
• Adenocarcinoma:*Intestinal type

• Mucinous type
• Clear cell type

• Signet-ring cell carcinoma
• Adenosquamous carcinoma
• Squamous cell carcinoma
• Small cell (oat cell) carcinoma
• Undifferentiated carcinoma

• Spindle cell type:*Giant cell type
• Small cell type

• Papillomatosis
• Papillary carcinoma:*Noninvasive
• Papillary carcinoma*:Invasive
• Carcinoma, NOS

Intrahepatic Bile Duct Cancer

• Mass-forming tumor growth pattern
• Periductal-infiltrating tumor growth pattern
• Mixed mass-forming and periductal-infiltrating growth pattern