Diverticulosis pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathogenesis
Diverticula develop at well-defined points of weakness, which correspond to where the vasa recta penetrate the circular muscle layer of the colon[1]. File:2015-11-02 6-30-46.jpg
A typical colonic diverticulum is a "false" or pulsion diverticulum, in which mucosa and submucosa herniate through the muscle layer,covered only by serosa. Abnormal colonic motility is an important predisposing factor in the development diverticula. Patients with diverticulosis have exaggerated segmentation contractions in which segmental muscular contractions separate the lumen into chambers. It is hypothesized that the increase in intraluminal pressure predisposes to herniation of mucosa and submucosa.
References
- ↑ Meyers MA, Alonso DR, Baer JW (1976). "Pathogenesis of massively bleeding colonic diverticulosis: new observations". AJR Am J Roentgenol. 127 (6): 901–8. doi:10.2214/ajr.127.6.901. PMID 1087123.