Subependymal giant cell astrocytoma MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Brain MRI may be helpful in the diagnosis of subependymal giant cell astrocytoma.
Findings on MRI suggestive of subependymal giant cell astrocytoma are tabulated below:^[1]


MRI component	Findings

T1	Heterogenous and hypo- to isointense to grey matter
T2	Heterogenous and hyperintense to grey matter Calcified components can be hypointense
T1 with gadolinium contrast	Marked homogenous or heterogenous enhancement

Other findings on MRI suggestive of subependymal giant cell astrocytoma include:^[2]

_{Two girls ([A] 9 and [B] 12 years old) with acute headaches and vomiting. On examination, both had papilledema. Brain magnetic resonance imaging shows ventricular subependymal giant cell astrocytomas with secondary hydrocephalus.^[3]}
_{This 6-year-old girl had a growing but asymptomatic tumor. (A) Her screening magnetic resonance imaging at age 2 revealed a subependymal giant cell astrocytoma with mild enlargement of the right lateral ventricle. (B) By age 6 years, the lesion had enlarged markedly.^[3]}
_{Subependymal giant cell astrocytoma of the type associated with tuberous sclerosis are typically bulky, contrast-enhancing mass in the region of the foramen of Monro. Most overlie the head of the caudate nucleus. Foramen obstruction has produced hydrocephalus.^[4]}

↑ Radiographic MRI features of subependymal giant cell astrocytoma. Dr Bruno Di Muzio and Dr Jeremy Jones et al. Radiopaedia 2015. http://radiopaedia.org/articles/subependymal-giant-cell-astrocytoma. Accessed on November 4, 2015
↑ Ouyang, Taohui; Zhang, Na; Benjamin, Thomas; Wang, Long; Jiao, Jiantong; Zhao, Yiqing; Chen, Jian (2014). "Subependymal giant cell astrocytoma: current concepts, management, and future directions". Child's Nervous System. 30 (4): 561–570. doi:10.1007/s00381-014-2383-x. ISSN 0256-7040.
↑ ^3.0 ^3.1 Roth, Jonathan; Roach, E. Steve; Bartels, Ute; Jóźwiak, Sergiusz; Koenig, Mary Kay; Weiner, Howard L.; Franz, David N.; Wang, Henry Z. (2013). "Subependymal Giant Cell Astrocytoma: Diagnosis, Screening, and Treatment. Recommendations From the International Tuberous Sclerosis Complex Consensus Conference 2012". Pediatric Neurology. 49 (6): 439–444. doi:10.1016/j.pediatrneurol.2013.08.017. ISSN 0887-8994.
↑ Radiology features of subependymal giant cell astrocytoma. Libre pathology 2015. http://librepathology.org/wiki/index.php/Subependymal_giant_cell_astrocytoma. Accessed on November 2, 2015