Cholangiocarcinoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Overview

Cholangiocarcinoma may be classified according to location of the tumor into three subtypes: extrahepatic bile duct cancer, perihilar bile duct cancer, and intrahepatic bile duct cancer.^[1] Perihilar cholangiocarcinoma may be classified according to Bismuth-Corlette classification into five subtypes based on the extent of ductal infiltration.

Classification

Cholangiocarcinoma may be classified according to location of the tumor into three subtypes:^[2]

Extrahepatic bile duct cancer
Perihilar bile duct cancer
Intrahepatic bile duct cancer

Cellular Classification of Cholangiocarcinoma

Extrahepatic Bile Duct Cancer

Carcinoma in situ
Adenocarcinoma, not otherwise specified (NOS)
Adenocarcinoma

Intestinal type
Mucinous type
Clear cell type

Signet-ring cell carcinoma
Adenosquamous carcinoma
Squamous cell carcinoma
Small cell (oat cell) carcinoma
Undifferentiated carcinoma

Spindle cell type
Giant cell type
Small cell type

Papillomatosis
Papillary carcinoma

Noninvasive

Papillary carcinoma
Invasive
Carcinoma, NOS

Perihilar Bile Duct Cancer The histologic types include the following:

Carcinoma in situ
Adenocarcinoma, not otherwise specified (NOS)
Adenocarcinoma

Intestinal type
Mucinous type
Clear cell type

Signet-ring cell carcinoma
Adenosquamous carcinoma
Squamous cell carcinoma
Small cell (oat cell) carcinoma
Undifferentiated carcinoma

Spindle cell type
Giant cell type
Small cell type

Papillomatosis
Papillary carcinoma

Noninvasive
Invasive

Carcinoma, NOS

Intrahepatic Bile Duct Cancer

Mass-forming tumor growth pattern
Periductal-infiltrating tumor growth pattern
Mixed mass-forming and periductal-infiltrating growth pattern

Bismuth-Corlette classification

Perihilar cholangiocarcinoma may be classified according to Bismuth-Corlette classification into five subtypes based on the extent of ductal infiltration:^[3]

Type I Limited to the common hepatic duct, below the level of the confluence of the right and left hepatic ducts

Type II Involves the confluence of the right and left hepatic ducts

Type IIIa Type II and extends to the bifurcation of the right hepatic duct

Type IIIb Type II and extends to the bifurcation of the left hepatic duct

Type IV Extending to the bifurcations of both right and left hepatic duct or multifocal involvement

Type V Stricture at the junction of common bile duct and cystic duct

References

↑ KLATSKIN G. "ADENOCARCINOMA OF THE HEPATIC DUCT AT ITS BIFURCATION WITHIN THE PORTA HEPATIS. AN UNUSUAL TUMOR WITH DISTINCTIVE CLINICAL AND PATHOLOGICAL FEATURES". Am J Med. 38: 241–56. PMID 14256720.
↑ KLATSKIN G. "ADENOCARCINOMA OF THE HEPATIC DUCT AT ITS BIFURCATION WITHIN THE PORTA HEPATIS. AN UNUSUAL TUMOR WITH DISTINCTIVE CLINICAL AND PATHOLOGICAL FEATURES". Am J Med. 38: 241–56. PMID 14256720.
↑ Cholangiocarcinoma. Radiopaedia. http://radiopaedia.org/articles/bismuth-corlette-classification

[1] KLATSKIN G. "ADENOCARCINOMA OF THE HEPATIC DUCT AT ITS BIFURCATION WITHIN THE PORTA HEPATIS. AN UNUSUAL TUMOR WITH DISTINCTIVE CLINICAL AND PATHOLOGICAL FEATURES". Am J Med. 38: 241–56. PMID 14256720.

[2] KLATSKIN G. "ADENOCARCINOMA OF THE HEPATIC DUCT AT ITS BIFURCATION WITHIN THE PORTA HEPATIS. AN UNUSUAL TUMOR WITH DISTINCTIVE CLINICAL AND PATHOLOGICAL FEATURES". Am J Med. 38: 241–56. PMID 14256720.

[radio-3] Cholangiocarcinoma. Radiopaedia. http://radiopaedia.org/articles/bismuth-corlette-classification

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