Hepatoblastoma risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Overview

Common risk factors in the development of hepatoblastoma are Aicardi syndrome, Beckwith-Wiedemann syndrome, familial adenomatous polyposis, low birth weight infants, and glycogen storage diseases.

Risk Factors

The table below lists risk factors for hepatoblastoma:

Associated Disorder	Clinical findings
Aicardi syndrome	Agenesis of the corpus callosum, chorioretinal lacunae, and infantile spasms, with a characteristic facies.
Beckwith-Wiedemann syndrome	Hemihypertrophy, hemihyperplasia.
Familial adenomatous polyposis	Adenoma, hepatoblastoma
Glycogen storage diseases I–IV	Symptoms vary by individual disorder.
Low birth weight infants	Preterm and small-for-gestation-age neonates.
Simpson-Golabi-Behmel syndrome	Macroglossia, macrosomia, renal and skeletal abnormalities, and increased risk of Wilms tumor.
Trisomy 18, other trisomies	Trisomy 18: Microcephaly and micrognathia, clenched fists with overlapping fingers, and failure to thrive. Most patients (>90%) die in the first month of life.

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