Chancroid differential diagnosis
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Overview
Chancroid must be differentiated from other diseases that cause genital ulcers and lymphadenopathy including syphilis, herpes simplex, dermatologic aspects of Behçet's disease, dermatologic manifestations of Lymphogranuloma venereum, donovanosis, and fixed drug eruption.
Differential Diagnosis of Chancroid
Chancroid must be differentiated from other diseases that cause genital ulcers and lymphadenopathy:
- Syphilis
- Herpes simplex
- Dermatologic aspects of Behçet's disease
- Dermatologic manifestations of Lymphogranuloma venereum
- Donovanosis
- Fixed drug eruption
Syphilitic chancres most closely resemble and chancroid lesion. A comparison is found below:
| Clinical Characteristic | Disease | |
|---|---|---|
| Syphilitic Chancre | Chancroid | |
| Mode of Transmission | Mainly sexual | Mainly sexual |
| Cause | Treponema pallidum | Haemophilus ducreyi |
| Lesion Type | Pustules that may progress to ulcers | Pustules that may progress to ulcers |
| Lesion Location | Genitals | Typically genitals; may occur on limbs |
| Lesion Size | Typically 1-2 cm in diameter | Typically 1-2 cm in diameter |
| Lesion Number | Multiple | 1-4 |
| Lesion Exudate | Typically non-exudative | Typically grey/yellow purulent exudate |
| Lesion Tenderness | Typically indurated | Typically soft |